PhD, SUNY-HSCB, 1994

Phone: (732) 235-4520
Fax: (732) 235-4029

email: casaccpa@umdnj.edu

Research interests:
Strategies for repair in demyelinating conditions, using adult neural stem cells. Identification of novel therapeutic targets for Multiple Sclerosis. Mechanisms of differentiation of lineage restricted oligodendrocyte progenitors. Molecular mechanisms of brain tumors.

Laboratory Home Page

Selected Publications 1

For complete list: PubMed

Gokhan, S., Marin-Husstege, M., Yu Yung , S, Fontanez, D., Casaccia-Bonnefil, P. Mehler, M.F. (2005) Coordinate Regulation of Homeodomain and Basic Helix-Loop-Helix Transcription Factors Differentially Regulate Myelin Basic Protein Gene Expression. J. Neurosci., 26:8311-8321.

Shen, S., Li, J., Casaccia-Bonnefil, P. (2005) Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. J. Cell Biol. 169: 577-589.

Bansal, R., Marin-Husstege,M., Winkler, S., Casaccia-Bonnefil, P. (2005) S-phase entry of oligodendrocyte lineage cells is associated with increased levels of p21Cip1. J. Neurosci. Res., 80:360-8.

Liu, A, Stadelman C., Mastronardi F., Moscarello M., Sobel A., Casaccia-Bonnefil, P. (2005) Expression of stathmin, a developmentally controlled cytoskeleton regulating molecule, in demyelinating disorders. J. Neurosci. 25:737-47.

Marin-Husstege, M., Muggironi, M., Raban, D., Skoff, R., Casaccia-Bonnefil, P. (2005) Oligodendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones. Dev. Neurosci. 26:245-54.

Crockett DP, Burshteyn M, Garcia C, Muggironi M, Casaccia-Bonnefil P. (2005) Number of oligodendrocyte progenitors recruited to the lesioned spinal cord is modulated by the levels of the cell cycle regulatory protein p27Kip-1. Glia. 49:301-8.

Kim, D., Zhao, X., Tu, C., Casaccia-Bonnefil, P., Chao, M.V. (2004) The neurotrophins prevent apoptotic but not necrotic cell death following neuronal injury by signaling through their TRK receptor. J. Neurosurgery , 100(1):79-87.

Liu A., M., Muggironi, M., Casaccia-Bonnefil, P. (2003) Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. Glia,44(3):264-74.

Petrone A., Dusa, A., Bianchi R., Casaccia-Bonnefil, P., Arancio, O., Sap.J. (2003) Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. EMBO J., 22:4121-4131.

Marin-Husstege, M., Muggironi, M., Liu A., Casaccia-Bonnefil, P. (2002) Histone deacetylase activity is necessary for oligodendrocyte lineage progression, J. Neurosci., 22: 10333-10345.

Doetsch, F. Verdugo, J.G., Caille I, Chao MV Alvarez-Buylla Casaccia-Bonnefil, P. (2002) Lack of the cell cycle inhibitor p27Kip1 results in selective increase of transit amplifying cells for adult neurogenesis. J. Neurosci, 22:2256-2264

Casaccia-Bonnefil, P., Carter, B., Dobrowsky, R.T. and Chao, M.V. (1996) Nerve growth factor mediated cell death of mature oligidendrocytes through the p75 neurotrophin receptor. Nature, 383, 716-719.