PhD, Case Western Reserve University, 1970

Phone: (732) 235-4528
Fax: (732) 235-4029

email: hitchcoc@umdnj.edu

Research interests:
Regulation of muscle contraction and cellular movement. Actin dynamics. Structure-function relationships in cytoskeletal proteins, protein structure and folding, coiled coils

Selected Publications 1

Greenfield, N.J., Palm, T. and Hitchcock-DeGregori, S.E. 2002 Structure and interactions of the carboxyl terminus of striated muscle a-tropomyosin: It is important to be flexible. Biophysical Journal, In press.

Palm, T., Graboski, S., Hitchcock-DeGregori, S.E. and Greenfield, N.J. 2001 Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region. Biophys. J., 81(5), 2827-2837.

Greenfield, N.J., Huang, Y.J., Palm, T., Swappna, G.V., Monleon, D., Monteglione, G.T. and Hitchcock-DeGregori, S.E. 2001 Solution NMR structure and folding dynamics of the N terminus of a rat non-muscle alpha-tropomyosin in an engineered chimeric protein. J. Mol. Biol., 312(4), 833-847.

Blanchoin, L. Pollard, T.D. and Hitchcock-DeGregori, S.E. 2001 Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin. Curr. Biol., 11(16), 1300-1304.

Hitchcock-DeGregori, S.E. Song, Y. and Moraczewska, J. 2001 Importance of internal regions and the overall length of tropomyosin for actin binding and regulatory function. Biochemistry, 40(7), 2104-2112.